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Learn about the causes, treatments, and symptoms. ACE inhibitors lower blood pressure by encouraging blood vessels to relax and open. Learn about the benefits and risks of these medications. Health Conditions Discover Plan Connect. Perindopril, Oral Tablet. Important warnings About Side effects Interactions Other warnings Dosage Take as directed Important considerations Alternatives Highlights for perindopril Perindopril oral tablet is available as a generic drug.
Perindopril comes only in the form of a tablet you take by mouth. Important warnings. What is perindopril? Perindopril side effects. Perindopril may interact with other medications. Perindopril warnings. How to take perindopril. Take as directed. Important considerations for taking perindopril. Are there any alternatives? Read this next. ACE inhibitors are a commonly prescribed and effective class of drugs used to manage high blood pressure, congestive heart failure and diabetic nephropathy.
Unfortunately, the irritation of the cough can be enough for some people to discontinue their medication and this could have very serious consequences. ACE inhibitors have a dual action on blood pressure. Firstly, they block the angiotensin-converting enzyme preventing blood vessels constricting.
A larger diameter blood vessel means lower pressure. Secondly, they inhibit the release of the hormone aldosterone. This increases the excretion of water and sodium, reducing the volume of fluid in your body and thereby decreasing blood pressure. Well, the mechanism of ACE inhibitor cough is not completely understood but most researchers believe it involves excess inflammatory proteins bradykinins and tachykinins accumulating in the upper airways.
These kinins are normally degraded by angiotensin converting enzyme but when they accumulate they cause excess production of nitric oxide, a molecule that is inflammatory and irritating to the lining of the airways. A randomised, doubled blinded placebo controlled trial of 19 patients with ACE inhibitors cough showed that iron supplementation of mg ferrous sulphate over four weeks significantly reduced the cough scores.
Well, we need to go back to the role of excess nitric oxide in triggering ACE inhibitor cough. If you begin to feel dizzy, lie down so that you don't faint, then sit until you feel better. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if they last longer than a week or are severe. If you're being sick, take small, frequent sips. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee.
Do not take any other medicines to treat diarrhoea or vomiting without speaking to a pharmacist or doctor. If you get diarrhoea or vomiting from a stomach bug or illness, tell your doctor. You may need to temporarily stop taking perindopril until you feel better. Check with the pharmacist to see what type is suitable for you. If it lasts for more than a day or two speak to your doctor as they may need to change your treatment. Perindopril and breastfeeding Small amounts of perindopril may get into breast milk.
Non-urgent advice: Tell your doctor if you're:. Tell your doctor if you're taking : anti-inflammatory medicines such as ibuprofen or indomethacin and aspirin for pain relief. Low-dose aspirin - 75mg a day - is safe to take with perindopril. Important: Medicine safety Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements. How does perindopril work? How long does perindopril take to work? How long will I take it for? Is perindopril safe to take for a long time?
What will happen if I stop taking it? Talk to your doctor if you want to stop taking perindopril. Can I come off perindopril now my blood pressure is lowered? Can I drink alcohol with it? Are there similar medicines to perindopril? There are also lots of other types of blood pressure-lowering medicines: calcium channel blockers - for example amlodipine angiotensin receptor blockers - for example candesartan beta blockers - for example bisoprolol diuretics - for example bendroflumethiazide If you can't take perindopril or other ACE inhibitor medicines because of side effects such as a dry cough, you may be able to switch to another blood pressure-lowering medicine.
What are the differences between perindopril and other ACE inhibitors? There are a few differences, though, between perindopril and other ACE inhibitors: perindopril can be used after a heart attack to prevent further ones, but some ACE inhibitors are not officially approved for this some ACE inhibitors are officially approved to be used in diabetic kidney disease, but perindopril is not you only need to be take perindopril once a day - some other ACE inhibitors need to be taken 3 times a day.
Can I take perindopril before surgery? Your doctor may advise you to stop taking it 24 hours before surgery. Is perindopril addictive? No, there's no evidence that perindopril is addictive. Will it affect my contraception? Perindopril won't affect any type of contraception. Will it affect my fertility? Is there any food or drink I need to avoid?
Can I drive or ride a bike? Can lifestyle changes help? Quit smoking - smoking increases your heart rate and blood pressure. Quitting smoking brings down your blood pressure and relieves heart failure symptoms.
Try to avoid secondhand smoke. Cut down on alcohol - drinking too much alcohol raises blood pressure over time. It makes heart failure worse too. Try to keep to the recommended guidelines of no more than 14 units of alcohol a week. A standard glass of wine ml is 2 units.
A pint of lager or beer is usually 2 to 3 units of alcohol. Exercise - regular exercise lowers blood pressure by keeping your heart and blood vessels in good condition. It doesn't need to be too energetic - walking every day will help. Eat well - aim to eat a diet that includes plenty of fruit and veg, wholegrains, fat-free or low-fat dairy products and lean proteins.
It's a good idea to cut down on salt too. Eating too much salt is the biggest cause of high blood pressure - the more salt you eat, the higher your blood pressure will be. ACE inhibition increases the cough reflex. The mechanisms underlying ACE inhibitor-induced cough are probably linked to suppression of kininase II activity, which may be followed by an accumulation of kinins, substance P and prostaglandins.
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